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Endocrine: Decreased carbohydrate and glucose tolerance, development of cushingoid state, glycosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic agents in diabetes, manifestations of latent diabetes mellitus, menstrual irregularities, postmenopausal vaginal hemorrhage, secondary adrenocortical and pituitary unresponsiveness (significantly in instances of stress, as in trauma, surgical procedure, or illness), suppression of growth in pediatric sufferers.
Within the literature, a small preliminary examine suggested that the use of topical agents (urea 40%, fluocinonide zero.05%, and tazarotene zero.1% cream) is efficient; a ≥2-grade enchancment in severity was reported in the majority of patients (58%).171 The result of a subsequent section 2 double-blind RCT evaluating these agents is anticipated.
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